Rna Processing Mechanisms Controlling Hiv Latency

Detection of Chimeric Cellular: HIV mRNAs Generated Through Aberrant Splicing in HIV-1 Latently Infected Resting CD4 T Cells

MYH Lee, G Khoury, M Olshansky, S Sonza, GP Carter, J McMahon, TP Stinear, SJ Turner, SR Lewin, DFJ Purcell

2022-04-28

Latent HIV-1 provirus in infected individuals on suppressive therapy does not always remain transcriptionally silent. Both HIV-1 L..

The RNA-Binding Proteins SRP14 and HMGB3 Control HIV-1 Tat mRNA Processing and Translation During HIV-1 Latency

G Khoury, MY Lee, SH Ramarathinam, J McMahon, AW Purcell, S Sonza, SR Lewin, DFJ Purcell

2021-06-14

HIV-1 Tat protein is essential for virus production. RNA-binding proteins that facilitate Tat production may be absent or downregu..

Multiply spliced HIV RNA is a predictive measure of virus production ex vivo and in vivo following reversal of HIV latency

JM Zerbato, G Khoury, W Zhao, MJ Gartner, RD Pascoe, A Rhodes, A Dantanarayana, M Gooey, J Anderson, P Bacchetti, SG Deeks, J McMahon, M Roche, TA Rasmussen, DF Purcell, SR Lewin

2021-03-01

Background: One strategy being pursued to clear latently infected cells that persist in people living with HIV (PLWH) on antiretro..

Optimization of 5-substituted thiazolyl ureas and 6-substituted imidazopyridines as potential HIV-1 latency reversing agents

W Nguyen, J Jacobson, KE Jarman, TR Blackmore, HJ Sabroux, SR Lewin, DF Purcell, BE Sleebs

2020-06-01

A persistent latent reservoir of virus in CD4⁺ T cells is a major barrier to cure HIV. Activating viral transcription i..

Functional properties and sequence variation of HTLV-1 p13

M Omsland, M Silic-Benussi, R Moles, S Sarkis, DFJ Purcell, D Yurick, G Khoury, DM D'Agostino, V Ciminale, G Franchini

2020-05-12

Human T cell leukemia virus type-1 (HTLV-1) was the first retrovirus found to cause cancer in humans, but the mechanisms that driv..

Tat IRES modulator of tat mRNA (TIM-TAM): A conserved RNA structure that controls Tat expression and acts as a switch for HIV productive and latent infection

G Khoury, C MacKenzie, L Ayadi, SR Lewin, C Branlant, DFJ Purcell

2020-03-18

Tat protein is essential to fully activate HIV transcription and processing of viral mRNA, and therefore determines virus expressi..

P30 protein: A critical regulator of HTLV-1 viral latency and host immunity

R Moles, S Sarkis, V Galli, M Omsland, DFJ Purcell, D Yurick, G Khoury, CA Pise-Masison, G Franchini

2019-12-18

The extraordinarily high prevalence of HTLV-1 subtype C (HTLV-1C) in some isolated indigenous communities in Oceania and the sever..

Role of HTLV-1 orf-I encoded proteins in viral transmission and persistence

S Sarkis, V Galli, R Moles, D Yurick, G Khoury, DFJ Purcell, G Franchini, CA Pise-Masison

2019-12-18

The human T cell leukemia virus type 1 (HTVL-1), first reported in 1980 by Robert Gallo's group, is the etiologic agent of both ca..

Identification of 5-Substituted 2-Acylaminothiazoles That Activate Tat-Mediated Transcription in HIV-1 Latency Models

W Nguyen, J Jacobson, KE Jarman, H Jousset Sabroux, L Harty, J McMahon, SR Lewin, DF Purcell, BE Sleebs

2019-05-23

The persistent reservoir of cells latently infected with human immunodeficiency virus (HIV)-integrated proviral DNA necessitates l..

Identification of Native and Posttranslationally Modified HLA-B*57:01-Restricted HIV Envelope Derived Epitopes Using Immunoproteomics

Sri H Ramarathinam, Stephanie Gras, Sheilajen Alcantara, Amanda WS Yeung, Nicole A Mifsud, Secondo Sonza, Patricia T Illing, Elias N Glaros, Robert J Center, Shane R Thomas, Stephen J Kent, Nicola Ternette, Damian FJ Purcell, Jamie Rossjohn, Anthony W Purcell

2018-06-01

The recognition of pathogen‐derived peptides by T lymphocytes is the cornerstone of adaptive immunity, whereby intracellular antig..

HIV latency reversing agents act through Tat post translational modifications

G Khoury, TM Mota, S Li, C Tumpach, MY Lee, J Jacobson, L Harty, JL Anderson, SR Lewin, DFJ Purcell

2018-05-11

Background: Different classes of latency reversing agents (LRAs) are being evaluated to measure their effects in reactivating HIV ..